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A novel study showed an interplay between macrophages and breast cancer cells through the TME, introducing HIF-1-stabilizing long noncoding RNA, lactate, and PHD2 [131]

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45 Interestingly, while UBE1 expression remains unchanged in human heart failure, experimental studies have shown that overexpression of UBE1 or UBE6 in neonatal rat ventricular cardiomyocytes (NRVCMs) increases the ubiquitination of Nav1.5, a major transmembrane protein essential for cardiomyocyte depolarization

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Moreover, the genera Roseburia and Megamonas were higher, and Escherichia/Shigella was lower in benign brain tumours than malignant brain tumours [183]