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doi: 10.1038/s41590-019-0407-0 33 BustamanteMFOliveiraPGGarcia-CarbonellRCroftAPSmithJMSerranoRLet al

(2012) support that E2 regulates the expression of Bcl-2, an anti-apoptotic protein, and survivin, which inhibits caspase activation, by the suppression of different miRNAs, including miR-16, miR-143 and miR-203

Because mTORC1 is a well-known regulator of metabolic functions, these findings imply that specific metabolic programs may underlie the unique characteristics of different B cell subsets