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This AT-specific ER stress directly impairs insulin signaling by promoting c-Jun N-terminal kinase (JNK)-mediated serine phosphorylation of insulin receptor substrate (IRS-1), reducing glucose uptake capacity by up to 60% (101)

Increased FDX1 activity and mitochondria-dependent energy metabolism are strong inducers of the cytotoxic effects of elesclomol-mediated cuproptosis (Tsvetkov et al., 2019) and inhibit Fe-S cluster biosynthesis (Tsvetkov et al., 2019)

Arwert EN, Hoste E, Watt FM

Alterations in gene expression may significantly influence skin aging by affecting metabolic pathways within skin cells (Schaum et al., 2020

Pharmacokinetics and pharmacodynamics of orally administered acetylenic tricyclic bis(cyanoenone), a highly potent Nrf2 activator with a reversible covalent mode of action

For instance, during mitochondrial respiration, the electron transport chain occasionally leaks electrons that react with molecular oxygen to form superoxide radicals (O2) [22]