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The observed skeletal benefits have been linked to combined effects on vascular development and regulation of growth factor-mediated pathways involved in bone remodeling

"2017 ACC Expert Consensus Decision Pathway on Management of Bleeding in Patients on Oral Anticoagulants: A Report of the American College of Cardiology Task Force on Expert Consensus Decision Pathways"

Nature 439:551556

The MAS comprises MDH1/2, GOT1/2, the malate--KG antiporter and the glutamate-aspartate antiporter, which exchanges mitochondrial -KG for cytosolic malate that is synthesized from oxaloacetic acid (OAA) by cytosolic MDH (Fig