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Brain histological analyses at 18 weeks post-soman exposure demonstrated significant reactive gliosis, characterized by increased numbers of activated microglia and reactive astroglia across the hippocampus, cortex, thalamus, and amygdala

Glutathione is an antioxidant

10.1042/CS20210468 35 De FloraS.BalanskyR.La MaestraS

Figure 8 4 Discussion In this study, we aimed to investigate the association between age and GSH levels in two critical higher-order processing brain regions involved in executive functions

[DOI] [PMC free article] [PubMed] [Google Scholar] 112.Mantovani A., Barajon I., Garlanda C

Indeed, animal model studies involving transgenic mice indicated hippocampal depletion of GSH precedes the elevation of A42/A40 ratio and the aggregation of the tau protein [32, 33]