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For example, with human cancer cell lines, Se-konjac glucomannan performed anti-proliferation properties against human lung cancer cells (A549) and human breast cancer cells (HCC1937) by activating mitochondria pro-apoptosis protein caspase-3 ( Table 3 shows positive results on the biological properties of Se-enriched plants and some food ingredients (microalgae, probiotics bacteria and milk casein) in the in vivo animal models compared with Se-enriched yeast, an alternative source of SeMet (around 60-84%) with a lower toxic effect ( Auricularia auricular mushroom and Se-enriched radish sprouts, showed similar effects on improving antioxidant activities such as GPx and catalase, lower malondialdehyde (MDA) levels, and protecting liver damages in high-fat diet mice ( Astragalus also has anti-inflammatory effects on diabetic mice by lower serum inflammation-related proteins, including C-reactive protein, tumor necrosis factor-alpha (TNF-), interleukin-6 (IL-6) and nuclear factor kappa B (NFB) ( Pyracantha fortuneana , and Se-enriched sweet potato inhibited tumor growth via apoptosis pathway and decreased IL-2, TNF-, and VEGF in mice xenograft with human cancer tumor ( TABLE 3 In vivo studies of Se-enriched plants and other food materials using animal models

A cell suspension containing 5 10 4 Luc-U87MG cells in 2 L of PBS (FUJIFILM Wako) was prepared an injected into the right cerebrum (under anesthesia) using an infusion system (Legato 130) and a flow rate of 1 L/min

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Kruis W, Fric P, Pokrotnieks J, et al

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