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Mutations in the enzymes responsible for homocysteine metabolism, particularly cystathionine -synthase (CBS) or 5,10-methylenetetrahydrofolate reductase (MTHFR), result in severe forms of HHcy

doi: 10.1016/j.neuroimage.2012.06.012

PMID: 39977233 Cardiovasc Res Cardiomyocyte II spectrin plays a critical role in maintaining cardiac function by regulating mitochondrial respiratory function

found that the molecular weight of PEG (e.g., Mw: 350, 1000, 2000, 3000) and the length of the anchoring lipid (e.g., C-14, C-18) affected the particle size of LNPs (DMPE-PEG 2000 : ~67 nm)