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539,540 Mitochondrial transplantation is an emerging treatment for diseases linked with mitochondrial dysfunction in which healthy mitochondria are isolated and transplanted back into tissues or organs to enhance the function of damaged cells

For each sample, the acquisition time was set to 10 s and the laser power at the sample was 5.0 mW 53

The cause of this fibrosis is not known (idiopathic)

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This disrupts membrane integrity, decreases mitochondrial membrane potential, and facilitates the release of pro-apoptotic factors such as cytochrome C (Cyt C) ( In DFUs, hyperglycemia disrupts the balance between pro-apoptotic (e.g., Bax) and anti-apoptotic (e.g., Bcl-2) proteins, triggering mitochondrial apoptosis (Wu et al., 2025)