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Lithospermic acid improves liver fibrosis through Piezo1-mediated oxidative stress and inflammation

Moreover, antioxidants quercetin (QE), baicalein (BE) and myricetin (ME) effectively downregulated ROS and MMP9 and inhibited glioma cell invasion/migration events in vitro ( However, some studies have shown that intake of antioxidants, such as carotenoids (371), vitamin E (372), and coffee (373), is not associated with the risk of developing gliomas

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Furthermore, inhibition of Rac1 activity by Rhein not only reduces oxidative stress but also affects downstream signaling pathways involved in EMT and renal fibrosis, such as the -catenin pathway (Xiong et al., 2023)

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