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However, whereas the majority of hepatotoxic compounds cause centrilobular injury, some xenobiotics, such as allyl formage, elemental phosphorus, and allyl alcohol, preferentially damage periportal hepatocytes, presumably as a result of rapid first-pass uptake by these upstream hepatocytes

Planta Daninha 34:377392 Alavanja MC, Bonner MR (2012) Occupational pesticide exposures and cancer risk: a review