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Review article: the clinical pharmacology of proton pump inhibitors

The maximum plasma concentrations (C(max)) of adducts for immediate release (IR) and extended release (ER) formulations were 0.108 (0.020) and 0.100 (0.028) nmol/mL serum, respectively, and were two orders of magnitude lower than the maximum APAP adduct levels previously reported in adults with acute liver failure secondary to APAP

10.3389/fnhum.2010.00210 140 WoodG.KoberS

Miyashita, E

More complex combined drug delivery systems further expand the treatment possibilities

Myocyte necrosis and oxygen supply reduction: Prolonged clenbuterol use (0.003-3 mmol/kg for 14 days) resulted in cardiac and skeletal muscle necrosis in rats, potentially due to reduced oxygen supply and increased muscle fatigability [29]