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Review of Ototoxic Drugs and Treatment Strategies for Reducing Hearing Loss

Further delineating this relationship, subcellular fractionation of CaSki cells following AP1M1 knockdown revealed Vangl1 accumulation across cytoplasmic, membrane, and cytoskeletal fractions (Figure 5f), closely resembling the pattern observed with E6/E7 knockdown

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Specifically, oxidative stress-induced activation of MAPK pathways can lead to phosphorylation of transcription factors and other signaling molecules, thereby promoting the expression of pro-inflammatory genes and contributing to airway inflammation and remodeling [121, 122]