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The mitochondrial matrix NADH can come from the TCA cycle or the photorespiratory process

It is one of the few compounds that improve SIX of all nine aging pathways

[Link] Beelman R.B., Kalaras M.D., Richie J.P., Micronutrients and Bioactive Compounds in Mushrooms: A Recipe for Healthy Aging?, Nutrition Today

J Biol Chem (2011) 286:4261525

A fetus inherits the disease only if both parents pass on a mutated allele, demonstrating the concept of compound heterozygosity if the inherited mutations differ