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207 ZieliskaM.RuszkiewiczJ.HilgierW.FrkoI.AlbrechtJ

doi:10.1016/j.stem.2013.11.002

Epoxyeicosanoid signaling provides multi-target protective effects on neurovascular unit in rats after focal ischemia

Nat Genet 53:14561468 Jung E, Osswald M, Ratliff M, Dogan H, Xie R, Weil S, Hoffmann DC, Kurz FT, Kessler T, Heiland S et al (2021) Tumor cell plasticity, heterogeneity, and resistance in crucial microenvironmental niches in glioma

However, PRP effects appear to be formulation-dependent, as some preparations, particularly those enriched with leukocytes, may also trigger transient inflammatory and oxidative signaling in tendon fibroblasts, which may partly explain the heterogeneity of clinical outcomes (Lansdown and Fortier, 2017)

These findings support the repurposing of leucovorin and dyclonine for clinical trials targeting myelin disorders, offering potential therapeutic avenues for PBI and MS