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If Phase 2 capacity is insufficient relative to Phase 1 activity, toxin clearance is impaired and symptom burden may increase rather than resolve

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To evaluate the capability of RL-GenRisk in identifying ccRCC risk genes with low mutation frequency but high risk, we utilized the maftools package 59 to analyze the mutation frequencies of the top 20 HRGs (Supplementary Table 1) identified by RL-GenRisk in ccRCC patients from TCGA (Supplementary Fig

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