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Considering the hindrance of transporter for successful delivery of neurotherapeutic agents, few reciprocating strategies such as (i) P-gp inhibition by usage of P-gp inhibitor drugs, (ii) by employing the structural activity of relationship for development of neuroprotective drug which conserves the essential pharmacological impact without being detected by P-gp transporter and (iii) incorporation of drug within carrier vector via Trojan horse mechanism to bypass the efflux transportation by ABC transporter

Microbiol Mol Biol Rev 80(3):793835

Purine is an essential component of DNA and RNA and is required for cell proliferation and survival [110, 111]

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