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Familial AD is usually correlated with mutations in 3 genes encoding amyloid precursor protein (APP) and the enzymatic components of -secretase complexes, including presenilin 1 (PS1) and presenilin 2 (PS2)

Morsy, A., El-Zaiat, H., Saber, A., Anwer, M., & Sallam, S

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Cells were treated with either glutathione diethyl ester (GDE) to enhance intracellular GSH or L-buthionine sulfoximine (L-BSO) to inhibit GSH synthesis

Phylum-level analysis (Figure S1D) revealed that the VPA-ASD group was dominated by Pseudomonadota (Proteobacteria), with elevated Deferribacterota and Campylobacterota, and severe depletion of Bacteroidota and Verrucomicrobiota

This ensures the body has what it needs to support a proper balance