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Perrard-Sapori MH, Chatelain PG, Jaillard C, Saez JM: Characterization and regulation of somatomedin-C/insulin-like growth factor I (Sm-C/IGF-I) receptors on cultured pig Leydig cells

As such, BSO is likely currently the most compelling drug to translate in a biomarker-directed (i.e., MYCN amplification) way

These cells express low -SMA and do not secrete collagens, suggesting that they are in a precursor state

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Evaluate the design requirements for enzyme-cleavable linkers to provide a scientific basis for subsequent design and ensure alignment with the overall project strategy