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From the differences in the kinetic and functional properties of the KC in normal and cancer cells, it may be possible to design strategies to specifically inhibit the energy metabolism in cancer cells without altering or minimizing the effects on the normal cells metabolism, in particular heart metabolism that is severed affected by the standard chemotherapy ( 2 Materials and methods 2.1 Chemicals Acetyl-Coenzyme A (Ac-CoA), ADP, coenzyme A (CoA), citrate, CS, DL-isocitrate (DL-Iso), IDH- NADP , 2-oxo, Suc, Fum, FH, malate (Mal), MDH, malic enzyme (ME), OAA, thiamine pyrophosphate (TPP), pyridoxal 5- phosphate (PP), NAD + , NADH, NADP + and NADPH were purchased from Sigma Chemical (St Louis, MO, USA)