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Additionally, FaDu cells were significantly more sensitive than normal human epithelial cells (HNEpCs) to BSO+AUR after 24 h, suggesting that BSO+AUR was preferentially toxic to HNSCC cells compared to normal untransformed cells ( Figure 3B )

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Activation of mTORC1 at late endosomes misdirects T cell fate decision in older individuals

Here, we report on an Fc-engineered variant with three amino acid substitutions Q311R/M428E/N434W (REW), that enhances plasma half-life and mucosal distribution, as well as allows for needle-free delivery across respiratory epithelial barriers in human FcRn transgenic mice