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and (ii) delivery-related issues, as PLGA nanoparticles require further engineering to achieve high selectivity and specificity, overcome BBB restrictions, and effectively target pathological sites, and/or multi-targeting strategies may be necessary as AD exhibits multiple pathological targets (Lu et al., 2023)

In contrast, another dual PPAR/ agonist, LY510929, which exerted antihyperlipidemic and antihyperglycemic effects in mice and rats (35), caused left ventricular hypertrophy in rats when was given for 2 weeks (36)