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Both amino acids are involved in complex metabolic pathways

Main text Role of oxidative stress in ALS ALS is an adult-onset neurodegenerative disease, characterized by degeneration and loss of upper motor neurons (MNs) in the cerebral cortex and lower MNs in the brainstem and spinal cord [69], leading to progressive weakness of voluntary muscles, and death caused by a diaphragmatic failure within 25 years [70, 71]

Limited mitochondrial permeabilization causes DNA damage and genomic instability in the absence of cell death

143 observed that overexpression of CMYC in human fibroblasts induced an increase in ROS levels, which correlated with the formation of foci of DNA damage

Notably, reports indicate that TMZ may also induce various forms of RCD, including necrosis, ferroptosis, and autophagy-dependent cell death (156)