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5,9 Others suggested a primary dysgenesis or degenerative process

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While recent years has witnessed a growing body of evidences showing demyelinating damages as a critical brain pathological change in neurodegenerative diseases such as Alzheimers disease (Wang et al., 2018) and various neuropsychiatric disorders such as major depression (Williams et al., 2019), schizophrenia (Miyata et al., 2015), and autism (Shen et al., 2018), the most representative and widely studied demyelinating disease is multiple sclerosis (MS)