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Importantly, the metabolic adaptations upon FH loss have been shown to be required for survival and could be used as a therapeutic strategy based on metabolic synthetic lethality [51]

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ATFs in macrophage activation and cytokine secretion Macrophage activation and cytokine secretion are orchestrated by ATFs that integrate microbial, metabolic and stress-derived signals, into coordinated transcriptional programs

Principal Investigator on A Double-Blind, Randomized, Parallel-Group Study with Quetiapine Extended Release as Comparator to Evaluate the Efficacy and Safety of Seltorexant 20 mg as Adjunctive Therapy to Antidepressants in Adult and Elderly Patients with Major Depressive Disorder with Insomnia Symptoms Who Have Responded Inadequately to Antidepressant Therapy. (Janssen)

H., Lin J