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Other Nutritional Signals to the GH-IGF-Axis Nutritional supplementation increasing dietary protein intake from cows milk increases endocrine IGF-I, while an equal intake of animal protein from meat does not (102)

However, for most people with normal B12 levels, supplementation or injections do not significantly affect metabolism or fat loss

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Overall, realistic expectation and a focus on holistic health improvements hold the greatest promise for long-term, sustainable weight management.