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In animal-model work, NNMT inhibition with 5-Amino-1MQ has been associated with changes in adipose-tissue mass, in NAD+ pool sizes (because NNMT consumes nicotinamide that would otherwise feed the NAD+ salvage pathway), and in methyl-donor dynamics (because NNMT consumes S-adenosylmethionine)

The combination also improves recovery, metabolism, and energy levels, offering a comprehensive approach to body recomposition

Protein-Protein Interactions Involving Enzymes of the Mammalian Methionine and Homocysteine Metabolism

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Department of Health and Human Services, ods.od.nih.gov/factsheets/VitaminB6-HealthProfessional/

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