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Ariadne RBR E3 ubiquitin protein ligase 2 is a pivotal downstream mediator in this process and is involved in aging-associated muscle degeneration and ubiquitin-dependent modification in skeletal muscle

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The resulting background-subtracted, run-day normalized lipid species concentrations were then used to calculate the lipid class concentrations

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Alterations of carbohydrate metabolism, where the ability of the body to manipulate and make use of glucose is extensively impaired