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There were many differences between the treatments used by the good responders and mild responders so there is a lot of possible "confounding factors"

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DNA polymerase gamma variants and hepatotoxicity during maintenance therapy of childhood acute lymphoblastic leukemia: Is there a causal relationship

The resulting -hydroxy-1, N 2 -propanoguanine-modified oligodeoxynucleotide was mixed at a 1:1 molar ratio with the complementary oligo: 5-[phos]-CCC TCT TCC GCT CTT CTT TC-3 in PBS and annealed at 85 C for 5 min, ramped to 25 C at 0.1 C s-1 and flash frozen immediately to prevent crosslink formation

doi:10.2174/1381612826666200717090334 Hoogeveen RC, Ballantyne CM