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Cellular and molecular life sciences

Acetoacetyl-CoA is converted to hydroxymethyl glutaryl-CoA (HMG-CoA) by the mitochondrial rate-limiting ketogenic enzyme 3-hydroxy-3-methylglutaryl-CoA synthase 2 (HMGCS2, EC 2.3.3.10) (Figure 1)

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Utley, A., Gonzalez, Y., Abbott, C., & Nykjaer, C

Supports metabolic flexibility in both fasted and fed states Useful for individuals with insulin resistance or post-cycle metabolic slowdown May complement fasting, low-carb, or Clean Carbs strategies for performance athletes MOTS-c administration significantly improved glucose tolerance and insulin sensitivity in aged and high-fat-fed mice. Lu et al., Aging Cell Promotes Fat Loss Without Muscle Breakdown By activating AMPK and mitochondrial uncoupling, MOTSc encourages the body to burn fat more efficiently especially during caloric restriction or training

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