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Studies (62, 63) have shown that sinomenine can inhibit the levels of inflammatory factors (TNF-, IL-6, NO, PGE2, iNOS and COX-2) in IL-1-induced RA-FLS, and inhibit the expression of TLR4, MyD88, p-NF-B p65 and TRAF-6 in RA-FLS, suggesting that sinomenine prevents IL-1-induced inflammation in human RA-FLS by inhibiting the TLR4/MyD88/NF-B signaling pathway

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Gut permeability and mucosal inflammation: bad, good or context dependent

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