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Overcoming IMiD resistance in T-cell lymphomas through potent degradation of ZFP91 and IKZF1

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Hypertension (high blood pressure) is very common, affecting about one in four adults in Salt

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CYP 450 Families and subfamilies Foye's principles of medicinal chemistry CYP Biotransformations Chemically diverse small molecules are converted, generally to more polar compounds Reactions include: Aliphatic hydroxylation, aromatic hydroxylation Dealkylation (N-,O-, S-) N-oxidation, S-oxidation Deamination Dehalogenation Oxidative Phase-I involving cytochrome P-450 enzymes: Aliphatic hydroxylation: Mainly occur on the ultimate () or penultimate (-1) carbon atom in the structure

4C), demonstrating the essential role of AMPK in this process