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Forcing conditions were applied using strains with exceptionally high levels of internal superoxide and H 2 O 2

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Growth retardation was observed in rats after two generations of selenium deficiency 62

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We further excluded two variants located in C1orf109 and TMEM161A genes, as the variant in C1orf109 was found 11 in homozygous state in the gnomAD database (v4.1.0), and the TMEM161A variant did not segregate with the phenotype