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(I've described my distaste for the entire concept of antidotes in a previous column, arguing that the term leads to muddy thinking and failure to weigh critically whether or not a specific intervention is indicated in individual cases.) Dr Juurlink is careful to point out that the vast majority of VPA overdose cases will not need a carbapenem because most patients improve with routine treatment

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Pharmacologically, modulating histone acetylation with LAC rapidly increased xCT and activated a network with mGlu2 receptors to prime enhanced glutamate homeostasis that promotes both pro-resilient and antidepressant-like responses (101)

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