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Many of these agents are not approved by the FDA for musculoskeletal indications and may be compounded or sourced outside regulated pharmaceutical manufacturing pathways

Our body is able to store some B12, therefore, it may take years for symptoms to present, Franklyn says

In addition to the ongoing studies and systematic review, the commenter stated that more research and comprehensive data are needed to evaluate these critical interventions, including the risks and benefits of the therapy options to different patient populations and to the continued availability of the blood supply

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Experienced researchers maintain relationships with multiple vendors and keep backup supplies of critical compounds