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Conversely, the ubiquitin ligase E3 HUWE1/MULE, which acts as a negative regulator of ferroptosis, regulates iron metabolism by targeting transferrin receptor 1 and counteracts abnormal iron accumulation, thereby alleviating acute liver injury caused by hepatic ischemia-reperfusion (I/R) [34]

Biochemistry 39:73747379 Chalapathi Rao ASV, Reddy AR (2008) Glutathione reductase: a putative redox regulatory system in plant cells

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