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In an example application as an anti-infective lock solution for intravascular catheters, the GSNO-CD solution exhibits potent antibacterial activities for both planktonic and biofilm bacteria, both intraluminal and extraluminal environments, both prevention and treatment of infections, and against multiple bacterial strains including a multidrug-resistant strain

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As AIP is a potent competitive PAL inhibitor, the buildup of phenylalanine without increased PAL activity likely explains the observed effects

Although still in early development, CAAR T therapy may hold particular promise for patients with refractory CLE in the context of systemic involvement

This suggests an extremely wide safety margin, at least in animal models