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Substances like CJC-1293, CJC-1295, sermorelin and tesamorelin, anamorelin, capromorelin, ibutamoren (MK-677), ipamorelin, lenomorelin (ghrelin), macimorelin, tabimorelin, GHRPs

& Dusheiko, G

Subsequently, secretion of GH and IGF-1 rapidly declines to very low levels in people aged 60 years or more, an event that was named somatopause (242, 245)

Brain Research, 906, 135142

Their hypothesis was based on the two in vitro evidence available at that time, i.e., (1) A-containing COOH-terminal fragment is toxic to cultured neurons (Neve et al., 1990), and (2) A alone exerts toxic effects on neurons, possibly through the serpin receptor (Roher et al., 1988