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Patients with severe, longstanding deficiency typically require longer recovery periods, with haematological improvement occurring over weeks and neurological recovery potentially taking months

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Treating a B12 deficiency is crucial since a severe deficiency can lead to nerve damage or neurological problems

If you are sensitive, or you experience fatigue as opposed to an increase in energy when taking vitamin B12 then using a smaller dose less frequently will likely be better for your body

This enrolled 390 people with type 2 diabetes, all on insulin, and randomised them to metformin 850 mg three times daily or placebo, with a follow-up of just over 4 years (de Jager et al, 2010)