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However, whether or not there is a close relationship between these mechanisms and how they may be combined to cause the downregulation of opioid receptors, especially MOR, under nerve-injury conditions still need further research

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group has received funding from the European Research Council (ERC) under the European Unions Horizon 2020 research and innovation programme (grant agreement 851647), the BBVA Foundation (Ayudas Fundacion BBVA a Proyectos de Investigacion Cientifica 2021 - Proyecto CoralCellSeq), and the Spanish Ministry of Science and Innovation (PID2021-124757NB-I00 funded by MCIN/AEI/10.13039/501100011033/ FEDER, UE)