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Novel insight into the molecular make-up of AMYRs and central signaling reinforces its key function in modulating homeostatic and hedonic feeding mechanisms

38 GjurasinM.MiklicP.ZupancicB.PerovicD.ZarkovicK.BrcicL.et al (2010)

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Cagrilintide: Long-acting amylin analog explained What cagrilintide is: Synthetic analog of human amylin hormone Also called "pramlintide long-acting" (related compound) Developed by Novo Nordisk Currently investigational (Phase 3 trials) Not yet FDA approved (as of 2024) Weekly subcutaneous injection Natural amylin background: Peptide hormone co-secreted with insulin Made by pancreatic beta cells Released after meals in response to nutrients Important satiety signal Regulates postprandial glucose Deficient in diabetes Why synthetic cagrilintide was developed: Natural amylin very short half-life (minutes) Impractical for treatment Cagrilintide engineered for long duration Weekly dosing vs multiple daily injections Better pharmacokinetics Enhanced stability Learn about peptides , how peptides work , and what are peptides used for at SeekPeptides

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Thermo Shandon Ltd., Abbey Ward, UK) for 24 h, then processed routinely to reach dehydration