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When copper metabolism is disrupted, either through excess copper or copper deficiency, it can trigger abnormal immune responses, thereby exacerbating neuronal damage, especially in neurodegenerative diseases such as ischemic stroke (200)

Suryawanshi et al

It is involved in the oxidative metabolism of many endogenous substances such as steroids and bile acids, as well as the detoxication of a wide variety of xenobiotics

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In Keap1 knockdown ( Keap1 KD ) mice, the Keap1 mRNA level is reduced to approximately 5% of that in wild-type mice, and constitutive Nrf2 activation is observed in various tissues, such as liver, lung, and kidney

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