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The intestinal barrier can become damaged from a variety of factors, including: A poor diet, high in processed carbohydrates and hydrogenated oils Food sensitivities Certain gut-irritating foods, such as grains, legumes, dairy and alcohol Low stomach acid Chronic stress Hormonal imbalances Medications, such as NSAIDS, antibiotics, steroids, contraceptives and chemotherapy drugs Chronic endurance exercise and overtraining Environmental toxins Infections and parasites Imbalance of the gut flora

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*Correspondence: Sang-Won Lee, [email protected] These authors have contributed equally to this work and share first authorship Disclaimer All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers

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62 There are suggestions that a combination of antioxidants and enzymes may be more effective in protecting against neuronal damage in PD