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Discovery of a novel class of ERR agonists

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Survivors and those presenting later in life develop progressive hematopoietic, neuroendocrine, and other systemic organ failure (Kearns-Sayre syndrome)

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To view a copy of this licence, visit About this article Cite this article Koppula, P., Zhuang, L

Given that the RFC provides a pathway for leucovorin calcium to enter the CNS in children who have reduced transport of folate across the bloodbrain barrier due to the FRA, we assume that the effect of leucovorin calcium is through an increase in 5MTHF in the CNS