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In the study Increased intake of calcium reverses vitamin B12 malabsorption induced by metformin , it was found that providing calcium supplementation to people taking metformin, was able to help prevent metformin-induced vitamin B12 deficiency

240 Palmitoylethanolamide (PEA) Reported dosage : 6001,200 mg daily PEA is an endocannabinoid-like compound naturally produced by the body that has been suggested to have anti-inflammatory, analgesic, and neuroprotective effects

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However, active absorption may be more efficient when supplementing with either small or high B12 doses

The deficiency is probably more common in those following vegan and strict vegetarian diets for at least some years