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doi: 10.1016/j.brainres.2018.09.032 86 LuanpitpongS.ChanvorachoteP.StehlikC.TseW.CalleryP

Lupus may also cause narrowing of the blood vessels

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Of note, CD40 is a transmembrane glycoprotein surface receptor, a member of the TNF receptor superfamily, and its activation is associated with increased effectiveness of antigen presentation and the upregulation of major histocompatibility complex class II and costimulatory molecules CD80/CD86

These metabolites can cross the BBB, modulate neuroinflammation by inhibiting HDAC activity, and enhance barrier integrity (Berding et al., 2021)