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Holman RR, Bethel MA, Mentz RJ, Thompson VP, Lokhnygina Y, Buse JB, Chan JC, Choi J, Gustavson SM, Iqbal N, et al
Iron plays a direct role in oxygen transport, and deficiency quickly shows in weak movement, pale mucous membranes, and poor weight gain
They produce water and an ionic salt, neither of which are acidic or basic ie: a NEUTRAL solution is produced
Given the continued accumulation of A plaques with age and disease progression, it is also suggested that microglial clearance of misfolded protein aggregates gradually fails over time (Hu et al., 2023)
This may be due to copper's ability to enhance the expression of metalloproteinases (MMPs).16 MMPs normally regulate the degradation of collagen, and a specific one, MMP-1, may be responsible for the initiation of collagen fragmentation.17 Supporting this, a 2024 study noted that elevated MMP-1 levels appear to contribute to aging skin and that higher MMP-1 levels in mice led to:18 The loss and fragmentation of dermal collagen fibrils Contracted fibroblast morphology Reduced collagen production Increased expression of pro-inflammatory mediators Additionally, a 2016 study found that GHK-Cu significantly increased gene expression of MMP-1 and MMP-2 at the lowest concentration, which the studys authors considered to be one of the reasons the peptide was able to increase collagen and elastin production.19 So, what this could ultimately mean is that using too much GHK-Cu (or other copper peptides) may in theory increase the skins MMP-1 concentration above the levels involved in healthy collagen production, taking it into the collagen fragmentation and breakdown territory seen in older skin with naturally higher MMP-1 levels
