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Importantly, BefA-mediated effects are independent of inflammatory cascades: administration of purified BefA or conditioned media enriched in BefA does not elevate pro-inflammatory cytokines and does not activate NF-B, JNK, or STAT1 signaling

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For a deeper look at the mechanism and clinical data, see our complete guide to what tesamorelin is and how it works

Cells were then stressed for 1 h using 250 M sodium arsenite and GFP-Trap SUMOylation Assay and Western Blot analysis was performed as previously described

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