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In AD and related tauopathies, hyperphosphorylated tau assembles into neurofibrillary tangles that impair proteasome activity and disrupt cellular homeostasis

Upregulation of urea transporter UT-A2 and water channels AQP2 and AQP3 in mice lacking urea transporter UT-B

These systems operate synergistically rather than in isolation, collectively maintaining female reproductive homeostasis through three principal mechanisms ( Figure 1 )