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The malignant and non-malignant cell associations form a TME, influencing cancer growth and progression

doi: 10.1016/j.medj.2024.02.002 16 SenguptaJN

431 In addition, airway microbial components may trigger lung carcinogenesis by inducing signaling pathways in oncogenes, such as Streptococcus and Veillonella -induced upregulation of the ERK and PI3K pathways

COMC-6 (2-crotonyloxymethyl-2-cyclohexenone) is a potent antitumor agent against both murine and human tumors in culture and in tumor-bearing mice ( Diarylsulfonylureas are a class of antitumor agent with interesting therapeutic efficacy against a wide range of cancers (Howbert et al., 1990

M.AbuzeidM

There is significant diversity within the Ruminococcus genus, with distinct subtypes of Ruminococcus exerting varying effects on the host organism [43, 44]