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Description

Impaired NLRP3 inflammasome activation/pyroptosis leads to robust inflammatory cell death via caspase-8/RIPK3 during coronavirus infection

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Acquired defects

Meanwhile, knockdown of ced-4 , a homolog to mammalian Apaf-1 that is required for apoptosis activation, did not significantly suppress starvation-induced mortality in daf-12(rh61rh411) and din-1(dh127) mutants after five days of starvation (Fig